Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell–mediated allergic response

Antigen-mediated cross-linking of IgE on mast cells triggers a signaling cascade that results in their degranulation and proinflammatory cytokine production, which are key effectors in allergic reactions. We show that the activation of mast cells is negatively regulated by the newly identified adapt...

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Publicado en:J Exp Med
Main Authors: Wang, Di, Zheng, Mingzhu, Qiu, Yuanjun, Guo, Chuansheng, Ji, Jian, Lei, Lei, Zhang, Xue, Liang, Jingjing, Lou, Jun, Huang, Wei, Dong, Bowen, Wu, Songquan, Wang, Jianli, Ke, Yuehai, Cao, Xuetao, Zhou, Yi Ting, Lu, Linrong
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267239/
https://ncbi.nlm.nih.gov/pubmed/25422497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140470
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