Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell–mediated allergic response

Antigen-mediated cross-linking of IgE on mast cells triggers a signaling cascade that results in their degranulation and proinflammatory cytokine production, which are key effectors in allergic reactions. We show that the activation of mast cells is negatively regulated by the newly identified adapt...

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Bibliografski detalji
Izdano u:J Exp Med
Glavni autori: Wang, Di, Zheng, Mingzhu, Qiu, Yuanjun, Guo, Chuansheng, Ji, Jian, Lei, Lei, Zhang, Xue, Liang, Jingjing, Lou, Jun, Huang, Wei, Dong, Bowen, Wu, Songquan, Wang, Jianli, Ke, Yuehai, Cao, Xuetao, Zhou, Yi Ting, Lu, Linrong
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2014
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267239/
https://ncbi.nlm.nih.gov/pubmed/25422497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140470
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