Genome-wide methylome analysis using MethylCap-seq uncovers 4 hypermethylated markers with high sensitivity for both adeno- and squamous-cell cervical carcinoma

BACKGROUND: Cytology-based screening methods for cervical adenocarcinoma (ADC) and to a lesser extent squamous-cell carcinoma (SCC) suffer from low sensitivity. DNA hypermethylation analysis in cervical scrapings may improve detection of SCC, but few methylation markers have been described for ADC....

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Rong, van Leeuwen, Robert W., Boers, Aniek, Klip, Harry G., de Meyer, Tim, Steenbergen, Renske D. M., van Criekinge, Wim, van der Zee, Ate G. J., Schuuring, Ed, Wisman, G. Bea A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348351/
https://ncbi.nlm.nih.gov/pubmed/27738327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12598
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