Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer

BACKGROUND: Despite an early response to platinum-based chemotherapy in advanced stage high-grade serous ovarian cancer (HGSOC), the majority of patients will relapse with drug-resistant disease. Aberrant epigenetic alterations like DNA methylation are common in HGSOC. Differences in DNA methylation...

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Detaylı Bibliyografya
Yayımlandı:BMC Med
Asıl Yazarlar: Tomar, Tushar, Alkema, Nicolette G., Schreuder, Leroy, Meersma, Gert Jan, de Meyer, Tim, van Criekinge, Wim, Klip, Harry G., Fiegl, Heidi, van Nieuwenhuysen, Els, Vergote, Ignace, Widschwendter, Martin, Schuuring, Ed, van der Zee, Ate G. J., de Jong, Steven, Wisman, G. Bea A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481993/
https://ncbi.nlm.nih.gov/pubmed/28641578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-017-0870-0
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