Identification of Novel Substrates for cGMP Dependent Protein Kinase (PKG) through Kinase Activity Profiling to Understand Its Putative Role in Inherited Retinal Degeneration

por Roy, Akanksha, Groten, John, Marigo, Valeria, Tomar, Tushar, Hilhorst, Riet
Publicado no Int J Mol Sci (2021)

Chick fetal organ spheroids as a model to study development and disease

por Dakhel, Soran, Davies, Wayne I. L., Joseph, Justin V., Tomar, Tushar, Remeseiro, Silvia, Gunhaga, Lena
Publicado no BMC Mol Cell Biol (2021)

Combined inhibition of SHP2 and MEK is effective in models of NF1-deficient malignant peripheral nerve sheath tumors

por Wang, Jiawan, Pollard, Kai, Allen, Amy N., Tomar, Tushar, Pijnenburg, Dirk, Yao, Zhan, Rodriguez, Fausto J., Pratilas, Christine A.
Publicado no Cancer Res (2020)

Kinome Array Profiling of Patient-Derived Pancreatic Ductal Adenocarcinoma Identifies Differentially Active Protein Tyrosine Kinases

por Creeden, Justin F., Alganem, Khaled, Imami, Ali S., Brunicardi, F. Charles, Liu, Shi-He, Shukla, Rammohan, Tomar, Tushar, Naji, Faris, McCullumsmith, Robert E.
Publicado no Int J Mol Sci (2020)

Protective effect of rosiglitazone on kidney function in high-fat challenged human-CRP transgenic mice: a possible role for adiponectin and miR-21?

por Morrison, Martine C., Yakala, Gopala K., Liang, Wen, Wielinga, Peter Y., Salic, Kanita, van Koppen, Arianne, Tomar, Tushar, Kleemann, Robert, Heeringa, Peter, Kooistra, Teake
Publicado no Sci Rep (2017)

Biobanking of patient and patient-derived xenograft ovarian tumour tissue: efficient preservation with low and high fetal calf serum based methods

por Alkema, Nicolette G., Tomar, Tushar, Duiker, Evelien W., Jan Meersma, Gert, Klip, Harry, van der Zee, Ate G. J., Wisman, G. Bea A., de Jong, Steven
Publicado no Sci Rep (2015)

Genome-wide methylation profiling of ovarian cancer patient-derived xenografts treated with the demethylating agent decitabine identifies novel epigenetically regulated genes and p...

por Tomar, Tushar, de Jong, Steven, Alkema, Nicolette G., Hoekman, Rieks L., Meersma, Gert Jan, Klip, Harry G., van der Zee, Ate GJ, Wisman, G. Bea A.
Publicado no Genome Med (2016)

Emerging Kinase Therapeutic Targets in Pancreatic Ductal Adenocarcinoma and Pancreatic Cancer Desmoplasia

por Creeden, Justin F., Alganem, Khaled, Imami, Ali S., Henkel, Nicholas D., Brunicardi, F. Charles, Liu, Shi-He, Shukla, Rammohan, Tomar, Tushar, Naji, Faris, McCullumsmith, Robert E.
Publicado no Int J Mol Sci (2020)

CSIG-37. TGF-β PROMOTES MEMBRANE TUBE FORMATION IN GLIOBLASTOMA THAT CONTRIBUTES TO INVASION AND THERAPY RESISTANCE

por Joseph, Justin, Grosch, Julia, Tomar, Tushar, Klink, Barbara, Daubon, Thomas, Rane, Lalit, Solecki, Gergely, Hasan-Olive, Mahdi, Hossain, Jubayer, Latif, Abdul, Ninzima, Sandra, Bergersen, Linda, Tardito, Saverio, Kruyt, Frank, Bjerkvig, Rolf, Winkler, Frank, Miletic, Hrvoje
Publicado no Neuro Oncol (2017)

Serum-Induced Differentiation of Glioblastoma Neurospheres Leads to Enhanced Migration/Invasion Capacity That Is Associated with Increased MMP9

por Joseph, Justin V., van Roosmalen, Ingrid A. M., Busschers, Ellen, Tomar, Tushar, Conroy, Siobhan, Eggens-Meijer, Ellie, Peñaranda Fajardo, Natalia, Pore, Milind M., Balasubramanyian, Veerakumar, Wagemakers, Michiel, Copray, Sjef, den Dunnen, Wilfred F. A., Kruyt, Frank A. E.
Publicado no PLoS One (2015)

Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer

por Tomar, Tushar, Alkema, Nicolette G., Schreuder, Leroy, Meersma, Gert Jan, de Meyer, Tim, van Criekinge, Wim, Klip, Harry G., Fiegl, Heidi, van Nieuwenhuysen, Els, Vergote, Ignace, Widschwendter, Martin, Schuuring, Ed, van der Zee, Ate G. J., de Jong, Steven, Wisman, G. Bea A.
Publicado no BMC Med (2017)

OTME-14. TGF-beta signaling in microtube formation of glioblastoma

por Storevik, Simon, Joseph, Justin, Magaut, Capucine, Henrique, Luiz, Mathivet, Thomas, Latif, Md Abdul, Rudewicz, Justine, Guyon, Joris, Gambaretti, Matteo, Haukås, Frida, Trones, Amalie, Ystaas, Lars Andreas Rømo, Hossain, Jubayer, Ninzima, Sandra, Zhou, Wenjing, Tomar, Tushar, Winkler, Frank, Kruyt, Frank, Bikfalvi, Andreas, Bjerkvig, Rolf, Daubon, Thomas, Miletic, Hrvoje
Publicado no Neurooncol Adv (2021)

Integrative kinome profiling identifies mTORC1/2 inhibition as treatment strategy in ovarian clear cell carcinoma

por Caumanns, Joseph J., Berns, Katrien, Wisman, G. Bea A., Fehrmann, Rudolf S.N., Tomar, Tushar, Klip, Harry, Meersma, Gert J., Hijmans, E. Marielle, Gennissen, Annemiek M.C., Duiker, Evelien W., Weening, Desiree, Itamochi, Hiroaki, Kluin, Roelof J.C., Reyners, Anna K.L., Birrer, Michael J., Salvesen, Helga B., Vergote, Ignace, van Nieuwenhuysen, Els, Brenton, James D., Braicu, E. Ioana, Kupryjanczyk, Jolanta, Spiewankiewicz, Beata, Mittempergher, Lorenza, Bernards, René, van der Zee, Ate G.J., de Jong, Steven
Publicado no Clin Cancer Res (2018)