Integrative kinome profiling identifies mTORC1/2 inhibition as treatment strategy in ovarian clear cell carcinoma

PURPOSE: Advanced stage ovarian clear cell carcinoma (OCCC) is unresponsive to conventional platinum-based chemotherapy. Frequent alterations in OCCC include deleterious mutations in the tumor suppressor ARID1A and activating mutations in the PI3K subunit PIK3CA. In this study, we aimed to identify...

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Publicado no:Clin Cancer Res
Main Authors: Caumanns, Joseph J., Berns, Katrien, Wisman, G. Bea A., Fehrmann, Rudolf S.N., Tomar, Tushar, Klip, Harry, Meersma, Gert J., Hijmans, E. Marielle, Gennissen, Annemiek M.C., Duiker, Evelien W., Weening, Desiree, Itamochi, Hiroaki, Kluin, Roelof J.C., Reyners, Anna K.L., Birrer, Michael J., Salvesen, Helga B., Vergote, Ignace, van Nieuwenhuysen, Els, Brenton, James D., Braicu, E. Ioana, Kupryjanczyk, Jolanta, Spiewankiewicz, Beata, Mittempergher, Lorenza, Bernards, René, van der Zee, Ate G.J., de Jong, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6098697/
https://ncbi.nlm.nih.gov/pubmed/29685880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3060
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