Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer

BACKGROUND: Despite an early response to platinum-based chemotherapy in advanced stage high-grade serous ovarian cancer (HGSOC), the majority of patients will relapse with drug-resistant disease. Aberrant epigenetic alterations like DNA methylation are common in HGSOC. Differences in DNA methylation...

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Pubblicato in:BMC Med
Autori principali: Tomar, Tushar, Alkema, Nicolette G., Schreuder, Leroy, Meersma, Gert Jan, de Meyer, Tim, van Criekinge, Wim, Klip, Harry G., Fiegl, Heidi, van Nieuwenhuysen, Els, Vergote, Ignace, Widschwendter, Martin, Schuuring, Ed, van der Zee, Ate G. J., de Jong, Steven, Wisman, G. Bea A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481993/
https://ncbi.nlm.nih.gov/pubmed/28641578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-017-0870-0
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