Human-Mouse Chimeras With Normal Expression and Function Reveal That Major Domain Swapping is Tolerated by P-glycoprotein (ABCB1)

The efflux transporter P-glycoprotein (P-gp) plays a vital role in the transport of molecules across cell membranes and has been shown to interact with a panoply of functionally and structurally unrelated compounds. How human P-gp interacts with this large number of drugs has not been well understoo...

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Pubblicato in:Biochemistry
Autori principali: Pluchino, Kristen M., Hall, Matthew D., Moen, Janna K., Chufan, Eduardo E., Fetsch, Patricia A., Shukla, Suneet, Gill, Deborah R., Hyde, Stephen C., Xia, Di, Ambudkar, Suresh V., Gottesman, Michael M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348299/
https://ncbi.nlm.nih.gov/pubmed/26820614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01064
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