Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells

Early after entry into monocytes, macrophages, dendritic cells, and resting CD4 T cells, HIV encounters a block, limiting reverse transcription (RT) of the incoming viral RNA genome. In this context, dNTP triphosphohydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) has been identified...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Baldauf, Hanna-Mari, Stegmann, Lena, Schwarz, Sarah-Marie, Ambiel, Ina, Trotard, Maud, Martin, Margarethe, Burggraf, Manja, Lenzi, Gina M., Lejk, Helena, Pan, Xiaoyu, Fregoso, Oliver I., Lim, Efrem S., Abraham, Libin, Nguyen, Laura A., Rutsch, Frank, König, Renate, Kim, Baek, Emerman, Michael, Fackler, Oliver T., Keppler, Oliver T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2017
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347584/
https://ncbi.nlm.nih.gov/pubmed/28228523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613635114
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