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The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx

The human SAMHD1 protein potently restricts lentiviral infection in dendritic cells and monocyte/macrophages, but is antagonized by the primate lentiviral protein Vpx which targets SAMHD1for degradation. However, only two of eight primate lentivirus lineages encode Vpx whereas its paralog, Vpr, is c...

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Main Authors: Lim, Efrem S., Fregoso, Oliver I., McCoy, Connor O., Matsen, Frederick A., Malik, Harmit S., Emerman, Michael
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288607/
https://ncbi.nlm.nih.gov/pubmed/22284954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.01.004
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