Loading...

The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx

The human SAMHD1 protein potently restricts lentiviral infection in dendritic cells and monocyte/macrophages, but is antagonized by the primate lentiviral protein Vpx which targets SAMHD1for degradation. However, only two of eight primate lentivirus lineages encode Vpx whereas its paralog, Vpr, is c...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Lim, Efrem S., Fregoso, Oliver I., McCoy, Connor O., Matsen, Frederick A., Malik, Harmit S., Emerman, Michael
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288607/
https://ncbi.nlm.nih.gov/pubmed/22284954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.01.004
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!