Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells

Early after entry into monocytes, macrophages, dendritic cells, and resting CD4 T cells, HIV encounters a block, limiting reverse transcription (RT) of the incoming viral RNA genome. In this context, dNTP triphosphohydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) has been identified...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Baldauf, Hanna-Mari, Stegmann, Lena, Schwarz, Sarah-Marie, Ambiel, Ina, Trotard, Maud, Martin, Margarethe, Burggraf, Manja, Lenzi, Gina M., Lejk, Helena, Pan, Xiaoyu, Fregoso, Oliver I., Lim, Efrem S., Abraham, Libin, Nguyen, Laura A., Rutsch, Frank, König, Renate, Kim, Baek, Emerman, Michael, Fackler, Oliver T., Keppler, Oliver T.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347584/
https://ncbi.nlm.nih.gov/pubmed/28228523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613635114
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