Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells

Early after entry into monocytes, macrophages, dendritic cells, and resting CD4 T cells, HIV encounters a block, limiting reverse transcription (RT) of the incoming viral RNA genome. In this context, dNTP triphosphohydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) has been identified...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Baldauf, Hanna-Mari, Stegmann, Lena, Schwarz, Sarah-Marie, Ambiel, Ina, Trotard, Maud, Martin, Margarethe, Burggraf, Manja, Lenzi, Gina M., Lejk, Helena, Pan, Xiaoyu, Fregoso, Oliver I., Lim, Efrem S., Abraham, Libin, Nguyen, Laura A., Rutsch, Frank, König, Renate, Kim, Baek, Emerman, Michael, Fackler, Oliver T., Keppler, Oliver T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347584/
https://ncbi.nlm.nih.gov/pubmed/28228523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613635114
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