Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity

Diabetes is associated with impaired glucose metabolism in the presence of excess insulin. Glucose and fatty acids provide reducing equivalents to mitochondria to generate energy, and studies have reported mitochondrial dysfunction in type II diabetes patients. If mitochondrial dysfunction can cause...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Morrow, Ryan M., Picard, Martin, Derbeneva, Olga, Leipzig, Jeremy, McManus, Meagan J., Gouspillou, Gilles, Barbat-Artigas, Sébastien, Dos Santos, Carlos, Hepple, Russell T., Murdock, Deborah G., Wallace, Douglas C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347565/
https://ncbi.nlm.nih.gov/pubmed/28223503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700997114
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