Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

β-Arrestins (βarrs) interact with G protein-coupled receptors (GPCRs) to desensitize G protein signaling, to initiate signaling on their own, and to mediate receptor endocytosis. Prior structural studies have revealed two unique conformations of GPCR–βarr complexes: the “tail” conformation, with βar...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Cahill, Thomas J., Thomsen, Alex R. B., Tarrasch, Jeffrey T., Plouffe, Bianca, Nguyen, Anthony H., Yang, Fan, Huang, Li-Yin, Kahsai, Alem W., Bassoni, Daniel L., Gavino, Bryant J., Lamerdin, Jane E., Triest, Sarah, Shukla, Arun K., Berger, Benjamin, Little, John, Antar, Albert, Blanc, Adi, Qu, Chang-Xiu, Chen, Xin, Kawakami, Kouki, Inoue, Asuka, Aoki, Junken, Steyaert, Jan, Sun, Jin-Peng, Bouvier, Michel, Skiniotis, Georgios, Lefkowitz, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347553/
https://ncbi.nlm.nih.gov/pubmed/28223524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701529114
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