The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1

The toroidal damage checkpoint complex Rad9–Rad1–Hus1 (9-1-1) has been characterized as a sensor of DNA damage. Flap endonuclease 1 (FEN1) is a structure-specific nuclease involved both in removing initiator RNA from Okazaki fragments and in DNA repair pathways. FEN1 activity is stimulated by prolif...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Wang, Wensheng, Brandt, Patrick, Rossi, Marie L., Lindsey-Boltz, Laura, Podust, Vladimir, Fanning, Ellen, Sancar, Aziz, Bambara, Robert A.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 2004
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC534749/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15556996/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0407686101
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