The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1

The toroidal damage checkpoint complex Rad9–Rad1–Hus1 (9-1-1) has been characterized as a sensor of DNA damage. Flap endonuclease 1 (FEN1) is a structure-specific nuclease involved both in removing initiator RNA from Okazaki fragments and in DNA repair pathways. FEN1 activity is stimulated by prolif...

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Hlavní autoři: Wang, Wensheng, Brandt, Patrick, Rossi, Marie L., Lindsey-Boltz, Laura, Podust, Vladimir, Fanning, Ellen, Sancar, Aziz, Bambara, Robert A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC534749/
https://ncbi.nlm.nih.gov/pubmed/15556996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407686101
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