A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy

Tau acetylation has recently emerged as a dominant post-translational modification (PTM) in Alzheimer’s disease (AD) and related tauopathies. Mass spectrometry studies indicate that tau acetylation sites cluster within the microtubule (MT)-binding region (MTBR), suggesting acetylation could regulate...

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Vydáno v:Sci Rep
Hlavní autoři: Trzeciakiewicz, Hanna, Tseng, Jui-Heng, Wander, Connor M., Madden, Victoria, Tripathy, Ashutosh, Yuan, Chao-Xing, Cohen, Todd J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347034/
https://ncbi.nlm.nih.gov/pubmed/28287136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44102
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