Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution

The success of targeted cancer therapy is limited by drug resistance that can result from tumor genetic heterogeneity. The current approach to address resistance typically involves initiating a new treatment after clinical/radiographic disease progression, ultimately resulting in futility in most pa...

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Udgivet i:Sci Rep
Main Authors: Jonsson, Vanessa D., Blakely, Collin M., Lin, Luping, Asthana, Saurabh, Matni, Nikolai, Olivas, Victor, Pazarentzos, Evangelos, Gubens, Matthew A., Bastian, Boris C., Taylor, Barry S., Doyle, John C., Bivona, Trever G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347024/
https://ncbi.nlm.nih.gov/pubmed/28287179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44206
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