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NF-κB activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer

Although oncogene-targeted therapy often elicits profound initial tumor responses in patients, responses are generally incomplete because some tumor cells survive initial therapy as residual disease that enables eventual acquired resistance. The mechanisms underlying tumor cell adaptation and surviv...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Blakely, Collin M., Pazarentzos, Evangelos, Olivas, Victor, Asthana, Saurabh, Yan, Jenny Jiacheng, Tan, Irena, Hrustanovic, Gorjan, Chan, Elton, Lin, Luping, Neel, Dana S., Newton, William, Bobb, Kathryn, Fouts, Timothy, Meshulam, Jeffrey, Gubens, Matthew A., Jablons, David M., Johnson, Jeffrey R., Bandyopadhyay, Sourav, Krogan, Nevan J., Bivona, Trever G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394036/
https://ncbi.nlm.nih.gov/pubmed/25843712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.03.012
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