Evolutionary Covariance Combined with Molecular Dynamics Predicts a Framework for Allostery in the MutS DNA Mismatch Repair Protein

[Image: see text] Mismatch repair (MMR) is an essential, evolutionarily conserved pathway that maintains genome stability by correcting base-pairing errors in DNA. Here we examine the sequence and structure of MutS MMR protein to decipher the amino acid framework underlying its two key activities—re...

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Bibliografske podrobnosti
izdano v:J Phys Chem B
Main Authors: Lakhani, Bharat, Thayer, Kelly M., Hingorani, Manju M., Beveridge, David L.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2017
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346969/
https://ncbi.nlm.nih.gov/pubmed/28135092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b11976
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