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Evolutionary Covariance Combined with Molecular Dynamics Predicts a Framework for Allostery in the MutS DNA Mismatch Repair Protein
[Image: see text] Mismatch repair (MMR) is an essential, evolutionarily conserved pathway that maintains genome stability by correcting base-pairing errors in DNA. Here we examine the sequence and structure of MutS MMR protein to decipher the amino acid framework underlying its two key activities—re...
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| Izdano u: | J Phys Chem B |
|---|---|
| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2017
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| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5346969/ https://ncbi.nlm.nih.gov/pubmed/28135092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b11976 |
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