JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species

The c-Jun NH(2)-terminal kinase (JNK) has been implicated in both cell death and survival responses to different stimuli. Here we reexamine the function of JNK in tumor necrosis factor (TNF)-stimulated cell death using fibroblasts isolated from wild-type, Mkk4(-/-) Mkk7(-/-), and Jnk1(-/-) Jnk2(-/-)...

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Detalhes bibliográficos
Main Authors: Ventura, Juan-Jose, Cogswell, Patricia, Flavell, Richard A., Baldwin, Albert S., Davis, Roger J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC534651/
https://ncbi.nlm.nih.gov/pubmed/15545623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1223004
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