Tumor necrosis factor and reactive oxygen species cooperative cytotoxicity is mediated via inhibition of NF-kappaB.

BACKGROUND: Tumor necrosis factor alpha (TNFalpha) plays a key role in pathogenesis of brain injury. However, TNFalpha exhibits no cytotoxicity in primary cultures of brain cells. This discrepancy suggests that other pathogenic stimuli that exist in the setting of brain injury precipitate TNFalpha c...

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Détails bibliographiques
Auteurs principaux: Ginis, I., Hallenbeck, J. M., Liu, J., Spatz, M., Jaiswal, R., Shohami, E.
Format: Artigo
Langue:Inglês
Publié: 2000
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949928/
https://ncbi.nlm.nih.gov/pubmed/11474119
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