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Combinatorial codon-based amino acid substitutions
Twenty Fmoc-protected trinucleotide phosphoramidites representing a complete set of codons for the natural amino acids were chemically synthesized for the first time. A pool of these reagents was incorporated into oligonucleotides at substoichiometric levels to generate two libraries of variants tha...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC534637/ https://ncbi.nlm.nih.gov/pubmed/15537836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gnh156 |
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