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Improved fluorescence assays to measure the defects associated with F508del‐CFTR allow identification of new active compounds
BACKGROUND AND PURPOSE: Cystic fibrosis (CF) is a debilitating disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which codes for a Clˉ/HCO(3)ˉ channel. F508del, the most common CF‐associated mutation, causes both gating and biogenesis defects in the...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5345687/ https://ncbi.nlm.nih.gov/pubmed/28094839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13715 |
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