Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency

Obstructive sleep apnea (OSA) is characterized by recurrent upper airway obstruction during sleep. OSA leads to high cardiovascular morbidity and mortality. The pathogenesis of OSA has been linked to a defect in neuromuscular control of the pharynx. There is no effective pharmacotherapy for OSA. The...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fleury Curado, Thomaz, Fishbein, Kenneth, Pho, Huy, Brennick, Michael, Dergacheva, Olga, Sennes, Luiz U., Pham, Luu V., Ladenheim, Ellen E., Spencer, Richard, Mendelowitz, David, Schwartz, Alan R., Polotsky, Vsevolod Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345079/
https://ncbi.nlm.nih.gov/pubmed/28281681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44392
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