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Mimicking enzyme evolution by generating new (βα)(8)-barrels from (βα)(4)-half-barrels

Gene duplication and fusion events that multiply and link functional protein domains are crucial mechanisms of enzyme evolution. The analysis of amino acid sequences and three-dimensional structures suggested that the (βα)(8)-barrel, which is the most frequent fold among enzymes, has evolved by the...

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Detaylı Bibliyografya
Asıl Yazarlar: Höcker, Birte, Claren, Jörg, Sterner, Reinhard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2004
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC534502/
https://ncbi.nlm.nih.gov/pubmed/15539462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405832101
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