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Mimicking enzyme evolution by generating new (βα)(8)-barrels from (βα)(4)-half-barrels
Gene duplication and fusion events that multiply and link functional protein domains are crucial mechanisms of enzyme evolution. The analysis of amino acid sequences and three-dimensional structures suggested that the (βα)(8)-barrel, which is the most frequent fold among enzymes, has evolved by the...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2004
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC534502/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15539462/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0405832101 |
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