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Mimicking enzyme evolution by generating new (βα)(8)-barrels from (βα)(4)-half-barrels
Gene duplication and fusion events that multiply and link functional protein domains are crucial mechanisms of enzyme evolution. The analysis of amino acid sequences and three-dimensional structures suggested that the (βα)(8)-barrel, which is the most frequent fold among enzymes, has evolved by the...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC534502/ https://ncbi.nlm.nih.gov/pubmed/15539462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405832101 |
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