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Autophagy maintains the metabolism and function of young and old (hematopoietic) stem cells

With age, hematopoietic stem cells (HSCs) lose their ability to regenerate the blood system, and promote disease development. Autophagy is associated with health and longevity, and is critical for protecting HSCs from metabolic stress. Here, we show that loss of autophagy in HSCs causes accumulation...

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Bibliografske podrobnosti
izdano v:Nature
Main Authors: Ho, Theodore T., Warr, Matthew R., Adelman, Emmalee R., Lansinger, Olivia M., Flach, Johanna, Verovskaya, Evgenia V., Figueroa, Maria E., Passegué, Emmanuelle
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344718/
https://ncbi.nlm.nih.gov/pubmed/28241143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21388
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