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Autophagy maintains the metabolism and function of young and old (hematopoietic) stem cells
With age, hematopoietic stem cells (HSCs) lose their ability to regenerate the blood system, and promote disease development. Autophagy is associated with health and longevity, and is critical for protecting HSCs from metabolic stress. Here, we show that loss of autophagy in HSCs causes accumulation...
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| Udgivet i: | Nature |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5344718/ https://ncbi.nlm.nih.gov/pubmed/28241143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21388 |
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