An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity

Alpha-1 adrenergic receptors (α1-ARs) play adaptive and protective roles in the heart. Dabuzalgron is an oral selective α1A-AR agonist that was well tolerated in multiple clinical trials of treatment for urinary incontinence, but has never been used to treat heart disease in humans or animal models....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JACC Basic Transl Sci
Prif Awduron: Beak, Ju Youn, Huang, Wei, Parker, Joel S., Hicks, Sean T., Patterson, Cam, Simpson, Paul C., Ma, Anqi, Jin, Jian, Jensen, Brian C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2017
Pynciau:
PRECLINICAL RESEARCH
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343290/
https://ncbi.nlm.nih.gov/pubmed/28286875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2016.10.006
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