An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity

Alpha-1 adrenergic receptors (α1-ARs) play adaptive and protective roles in the heart. Dabuzalgron is an oral selective α1A-AR agonist that was well tolerated in multiple clinical trials of treatment for urinary incontinence, but has never been used to treat heart disease in humans or animal models....

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Dades bibliogràfiques
Publicat a:JACC Basic Transl Sci
Autors principals: Beak, Ju Youn, Huang, Wei, Parker, Joel S., Hicks, Sean T., Patterson, Cam, Simpson, Paul C., Ma, Anqi, Jin, Jian, Jensen, Brian C.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017
Matèries:
PRECLINICAL RESEARCH
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343290/
https://ncbi.nlm.nih.gov/pubmed/28286875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2016.10.006
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