An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice

Alpha-1 adrenergic receptors mediate adaptive effects in the heart and cardiac myocytes, and a myocyte survival pathway involving the alpha-1A receptor subtype and ERK activation exists in vitro. However, data in vivo are limited. Here we tested A61603 (N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-...

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Publicat a:PLoS One
Autors principals: Montgomery, Megan D., Chan, Trevor, Swigart, Philip M., Myagmar, Bat-erdene, Dash, Rajesh, Simpson, Paul C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5231318/
https://ncbi.nlm.nih.gov/pubmed/28081170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168409
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