Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments

Hypoxia is a poor-prognosis microenvironmental hallmark of solid tumours, but it is unclear how it influences the fate of disseminated tumour cells (DTCs) in target organs. Here we report that hypoxic HNSCC and breast primary tumour microenvironments displayed upregulation of key dormancy (NR2F1, DE...

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Bibliografske podrobnosti
izdano v:Nat Cell Biol
Main Authors: Fluegen, Georg, Avivar-Valderas, Alvaro, Wang, Yarong, Padgen, Michael R., Williams, James K., Nobre, Ana Rita, Calvo, Veronica, Cheung, Julie F., Bravo-Cordero, Jose Javier, Entenberg, David, Castracane, James, Verkhusha, Vladislav, Keely, Patricia J., Condeelis, John, Aguirre-Ghiso, Julio A.
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342902/
https://ncbi.nlm.nih.gov/pubmed/28114271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3465
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