Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments

Hypoxia is a poor-prognosis microenvironmental hallmark of solid tumours, but it is unclear how it influences the fate of disseminated tumour cells (DTCs) in target organs. Here we report that hypoxic HNSCC and breast primary tumour microenvironments displayed upregulation of key dormancy (NR2F1, DE...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Fluegen, Georg, Avivar-Valderas, Alvaro, Wang, Yarong, Padgen, Michael R., Williams, James K., Nobre, Ana Rita, Calvo, Veronica, Cheung, Julie F., Bravo-Cordero, Jose Javier, Entenberg, David, Castracane, James, Verkhusha, Vladislav, Keely, Patricia J., Condeelis, John, Aguirre-Ghiso, Julio A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342902/
https://ncbi.nlm.nih.gov/pubmed/28114271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3465
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