Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments

Hypoxia is a poor-prognosis microenvironmental hallmark of solid tumours, but it is unclear how it influences the fate of disseminated tumour cells (DTCs) in target organs. Here we report that hypoxic HNSCC and breast primary tumour microenvironments displayed upregulation of key dormancy (NR2F1, DE...

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Bibliografiska uppgifter
I publikationen:Nat Cell Biol
Huvudupphovsmän: Fluegen, Georg, Avivar-Valderas, Alvaro, Wang, Yarong, Padgen, Michael R., Williams, James K., Nobre, Ana Rita, Calvo, Veronica, Cheung, Julie F., Bravo-Cordero, Jose Javier, Entenberg, David, Castracane, James, Verkhusha, Vladislav, Keely, Patricia J., Condeelis, John, Aguirre-Ghiso, Julio A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342902/
https://ncbi.nlm.nih.gov/pubmed/28114271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3465
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