Exocytosis of polyubiquitinated proteins in bortezomib-resistant leukemia cells: a role for MARCKS in acquired resistance to proteasome inhibitors

PSMB5 mutations and upregulation of the β5 subunit of the proteasome represent key determinants of acquired resistance to the proteasome inhibitor bortezomib (BTZ) in leukemic cells in vitro. We here undertook a multi-modality (DNA, mRNA, miRNA) array-based analysis of human CCRF-CEM leukemia cells...

Full description

Saved in:
Bibliographic Details
Published in:Oncotarget
Main Authors: Franke, Niels E., Kaspers, Gertjan L., Assaraf, Yehuda G., van Meerloo, Johan, Niewerth, Denise, Kessler, Floortje L., Poddighe, Pino J., Kole, Jeroen, Smeets, Serge J., Ylstra, Bauke, Bi, Chonglei, Chng, Wee Joo, Horton, Terzah M., Menezes, Rene X., Musters, Renée J.P., Zweegman, Sonja, Jansen, Gerrit, Cloos, Jacqueline
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342701/
https://ncbi.nlm.nih.gov/pubmed/27542283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11340
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items