Antileukemic Activity and Mechanism of Drug Resistance to the Marine Salinispora tropica Proteasome Inhibitor Salinosporamide A (Marizomib)

Salinosporamide A (NPI-0052, marizomib) is a naturally occurring proteasome inhibitor derived from the marine actinobacterium Salinispora tropica, and represents a promising clinical agent in the treatment of hematologic malignancies. Recently, these actinobacteria were shown to harbor self-resistan...

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Main Authors: Niewerth, Denise, Jansen, Gerrit, Riethoff, Lesley F. V., van Meerloo, Johan, Kale, Andrew J., Moore, Bradley S., Assaraf, Yehuda G., Anderl, Janet L., Zweegman, Sonja, Kaspers, Gertjan J. L., Cloos, Jacqueline
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2014
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054006/
https://ncbi.nlm.nih.gov/pubmed/24737138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.092114
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