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Generating a Generation of Proteasome Inhibitors: From Microbial Fermentation to Total Synthesis of Salinosporamide A (Marizomib) and Other Salinosporamides

The salinosporamides are potent proteasome inhibitors among which the parent marine-derived natural product salinosporamide A (marizomib; NPI-0052; 1) is currently in clinical trials for the treatment of various cancers. Methods to generate this class of compounds include fermentation and natural pr...

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Detalhes bibliográficos
Main Authors: Potts, Barbara C., Lam, Kin S.
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Diversity Preservation International 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866466/
https://ncbi.nlm.nih.gov/pubmed/20479958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md8040835
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