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Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A
Proteasome inhibitors have recently emerged as a therapeutic strategy in cancer chemotherapy but susceptibility to drug resistance limits their efficacy. The marine actinobacterium Salinispora tropica produces salinosporamide A (NPI-0052, marizomib), a potent proteasome inhibitor and promising clini...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3220761/ https://ncbi.nlm.nih.gov/pubmed/21882868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb2002544 |
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