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Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A
Proteasome inhibitors have recently emerged as a therapeutic strategy in cancer chemotherapy but susceptibility to drug resistance limits their efficacy. The marine actinobacterium Salinispora tropica produces salinosporamide A (NPI-0052, marizomib), a potent proteasome inhibitor and promising clini...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3220761/ https://ncbi.nlm.nih.gov/pubmed/21882868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb2002544 |
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