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Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A

Proteasome inhibitors have recently emerged as a therapeutic strategy in cancer chemotherapy but susceptibility to drug resistance limits their efficacy. The marine actinobacterium Salinispora tropica produces salinosporamide A (NPI-0052, marizomib), a potent proteasome inhibitor and promising clini...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Kale, Andrew J., McGlinchey, Ryan P., Lechner, Anna, Moore, Bradley S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220761/
https://ncbi.nlm.nih.gov/pubmed/21882868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb2002544
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