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Function-Oriented Biosynthesis of β-Lactone Proteasome Inhibitors in Salinispora tropica
The natural proteasome inhibitor salinosporamide A from the marine bacterium Salinispora tropica is a promising drug candidate for the treatment of multiple myeloma and mantle cell lymphoma. Using a comprehensive approach that combined chemical synthesis with metabolic engineering, we generated a se...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2771571/ https://ncbi.nlm.nih.gov/pubmed/19746976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901098m |
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