Exocytosis of polyubiquitinated proteins in bortezomib-resistant leukemia cells: a role for MARCKS in acquired resistance to proteasome inhibitors

PSMB5 mutations and upregulation of the β5 subunit of the proteasome represent key determinants of acquired resistance to the proteasome inhibitor bortezomib (BTZ) in leukemic cells in vitro. We here undertook a multi-modality (DNA, mRNA, miRNA) array-based analysis of human CCRF-CEM leukemia cells...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Franke, Niels E., Kaspers, Gertjan L., Assaraf, Yehuda G., van Meerloo, Johan, Niewerth, Denise, Kessler, Floortje L., Poddighe, Pino J., Kole, Jeroen, Smeets, Serge J., Ylstra, Bauke, Bi, Chonglei, Chng, Wee Joo, Horton, Terzah M., Menezes, Rene X., Musters, Renée J.P., Zweegman, Sonja, Jansen, Gerrit, Cloos, Jacqueline
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342701/
https://ncbi.nlm.nih.gov/pubmed/27542283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11340
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