Exocytosis of polyubiquitinated proteins in bortezomib-resistant leukemia cells: a role for MARCKS in acquired resistance to proteasome inhibitors

PSMB5 mutations and upregulation of the β5 subunit of the proteasome represent key determinants of acquired resistance to the proteasome inhibitor bortezomib (BTZ) in leukemic cells in vitro. We here undertook a multi-modality (DNA, mRNA, miRNA) array-based analysis of human CCRF-CEM leukemia cells...

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Vydáno v:Oncotarget
Hlavní autoři: Franke, Niels E., Kaspers, Gertjan L., Assaraf, Yehuda G., van Meerloo, Johan, Niewerth, Denise, Kessler, Floortje L., Poddighe, Pino J., Kole, Jeroen, Smeets, Serge J., Ylstra, Bauke, Bi, Chonglei, Chng, Wee Joo, Horton, Terzah M., Menezes, Rene X., Musters, Renée J.P., Zweegman, Sonja, Jansen, Gerrit, Cloos, Jacqueline
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342701/
https://ncbi.nlm.nih.gov/pubmed/27542283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11340
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