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PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells

Cancer cells are thought to use actin rich invadopodia to facilitate matrix degradation. Formation and maturation of invadopodia requires the co-ordained activity of Rho-GTPases, however the molecular mechanisms that underlie the invadopodia lifecycle are not fully elucidated. Previous work has sugg...

詳細記述

保存先:
書誌詳細
出版年:Oncotarget
主要な著者: Nicholas, Nicole S., Pipili, Aikaterini, Lesjak, Michaela S., Ameer, Simon M., Geh, Jenny L. C., Healy, Ciaran, Ross, Alistair D. MacKenzie, Parsons, Maddy, Nestle, Frank O., Lacy, Katie E., Wells, Claire M.
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342596/
https://ncbi.nlm.nih.gov/pubmed/27765920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12282
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