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PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells
Cancer cells are thought to use actin rich invadopodia to facilitate matrix degradation. Formation and maturation of invadopodia requires the co-ordained activity of Rho-GTPases, however the molecular mechanisms that underlie the invadopodia lifecycle are not fully elucidated. Previous work has sugg...
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| 出版年: | Oncotarget |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Impact Journals LLC
2016
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5342596/ https://ncbi.nlm.nih.gov/pubmed/27765920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12282 |
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