PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells

Cancer cells are thought to use actin rich invadopodia to facilitate matrix degradation. Formation and maturation of invadopodia requires the co-ordained activity of Rho-GTPases, however the molecular mechanisms that underlie the invadopodia lifecycle are not fully elucidated. Previous work has sugg...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Nicholas, Nicole S., Pipili, Aikaterini, Lesjak, Michaela S., Ameer, Simon M., Geh, Jenny L. C., Healy, Ciaran, Ross, Alistair D. MacKenzie, Parsons, Maddy, Nestle, Frank O., Lacy, Katie E., Wells, Claire M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342596/
https://ncbi.nlm.nih.gov/pubmed/27765920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12282
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