Vemurafenib-resistant BRAF-V600E-mutated melanoma is regressed by MEK-targeting drug trametinib, but not cobimetinib in a patient-derived orthotopic xenograft (PDOX) mouse model

Melanoma is a recalcitrant disease. The present study used a patient-derived orthotopic xenograft (PDOX) model of melanoma to test sensitivity to three molecularly-targeted drugs and one standard chemotherapeutic. A BRAF-V600E-mutant melanoma obtained from the right chest wall of a patient was grown...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Kawaguchi, Kei, Murakami, Takashi, Chmielowski, Bartosz, Igarashi, Kentaro, Kiyuna, Tasuku, Unno, Michiaki, Nelson, Scott D., Russell, Tara A., Dry, Sarah M., Li, Yunfeng, Eilber, Fritz C., Hoffman, Robert M.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342117/
https://ncbi.nlm.nih.gov/pubmed/27690220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12328
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars