Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer

The mechanistic target of rapamycin (mTOR) is a rational target for cancer treatment. While the mTORC1-selective rapalogs have shown significant benefits in the clinic, antitumor response may be further improved by inhibiting both mTORC1 and mTORC2. Herein, we established target profile of a novel m...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Qian, Jianchang, Chen, Yaqing, Meng, Tao, Ma, Lanping, Meng, Lanfang, Wang, Xin, Yu, Ting, Zask, Arie, Shen, Jingkang, Yu, Ker
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341858/
https://ncbi.nlm.nih.gov/pubmed/27563814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11490
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