Mitophagy and Alzheimer’s disease: cellular and molecular mechanisms

Neurons affected in Alzheimer’s disease (AD) experience mitochondrial dysfunction and a bioenergetic deficit that occurs early and promotes the disease-defining amyloid β-peptide (Aβ) and Tau pathologies. Emerging findings suggest that the autophagy – lysosome pathway that removes damaged mitochondr...

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Bibliographic Details
Published in:Trends Neurosci
Main Authors: Kerr, Jesse S., Adriaanse, Bryan A., Greig, Nigel H., Mattson, Mark P., Cader, M. Zameel, Bohr, Vilhelm A., Fang, Evandro F.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341618/
https://ncbi.nlm.nih.gov/pubmed/28190529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tins.2017.01.002
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