Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

Accumulation of damaged mitochondria is a hallmark of aging and age-related neurodegeneration, including Alzheimer’s disease (AD). The molecular mechanisms of impaired mitochondrial homeostasis in AD are being investigated. Here we provide evidence that mitophagy is impaired in the hippocampus of AD...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Fang, Evandro F., Hou, Yujun, Palikaras, Konstantinos, Adriaanse, Bryan A., Kerr, Jesse S., Yang, Beimeng, Lautrup, Sofie, Hasan-Olive, Md Mahdi, Caponio, Domenica, Dan, Xiuli, Rocktäschel, Paula, Croteau, Deborah L., Akbari, Mansour, Greig, Nigel H., Fladby, Tormod, Nilsen, Hilde, Cader, M. Zameel, Mattson, Mark P., Tavernarakis, Nektarios, Bohr, Vilhelm A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693625/
https://ncbi.nlm.nih.gov/pubmed/30742114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0332-9
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