Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

Accumulation of damaged mitochondria is a hallmark of aging and age-related neurodegeneration, including Alzheimer’s disease (AD). The molecular mechanisms of impaired mitochondrial homeostasis in AD are being investigated. Here we provide evidence that mitophagy is impaired in the hippocampus of AD...

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Detaylı Bibliyografya
Yayımlandı:Nat Neurosci
Asıl Yazarlar: Fang, Evandro F., Hou, Yujun, Palikaras, Konstantinos, Adriaanse, Bryan A., Kerr, Jesse S., Yang, Beimeng, Lautrup, Sofie, Hasan-Olive, Md Mahdi, Caponio, Domenica, Dan, Xiuli, Rocktäschel, Paula, Croteau, Deborah L., Akbari, Mansour, Greig, Nigel H., Fladby, Tormod, Nilsen, Hilde, Cader, M. Zameel, Mattson, Mark P., Tavernarakis, Nektarios, Bohr, Vilhelm A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693625/
https://ncbi.nlm.nih.gov/pubmed/30742114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0332-9
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